21 Low-Carb Protein Casserole Recipes for Weight Loss & Energy

If you’re following a low-carb lifestyle or looking for protein-packed meals that support weight loss without sacrificing flavor, casseroles are your new best friend. They’re easy to prepare, family-friendly, filling, and perfect for meal prep.

In this post, you’ll discover 21 low-carb protein casserole recipes with simple instructions that are ideal for fat loss, muscle building, and keeping your energy steady all day.

Why Low-Carb Protein Casseroles Are Perfect for Fat Loss

1. High in Protein – Keeps you full longer and helps preserve lean muscle.
2. Low in Carbs – Supports fat loss and stabilizes blood sugar.
3. Meal Prep Friendly – Make once, enjoy all week.
4. Family Approved – Comfort food made healthy.
5. Endless Variety – Chicken, beef, seafood, and vegetarian options.

21 Low-Carb Protein Casserole Recipes with Instructions

1. Cheesy Chicken & Broccoli Casserole

• Ingredients: Chicken breast, broccoli, cream cheese, shredded cheddar, garlic powder.
• Instructions: Cook chicken, steam broccoli, mix with cream cheese and spices. Top with cheddar and bake at 375°F for 20 minutes.

2. Beef Taco Casserole

• Ingredients: Ground beef, taco seasoning, eggs, shredded cheese, salsa.
• Instructions: Brown beef with seasoning, stir in eggs and salsa, pour into baking dish. Top with cheese and bake 25 minutes at 350°F.

3. Buffalo Chicken Casserole

• Ingredients: Shredded chicken, cauliflower rice, cream cheese, buffalo sauce, mozzarella.
• Instructions: Mix chicken, cauliflower rice, cream cheese, and buffalo sauce. Spread in dish, top with mozzarella, bake 20 minutes at 375°F.

4. Eggplant & Ground Turkey Casserole

• Ingredients: Eggplant slices, ground turkey, marinara (sugar-free), mozzarella.
• Instructions: Layer roasted eggplant, cooked turkey with marinara, and mozzarella. Repeat layers and bake 30 minutes at 375°F.

5. Zucchini Noodle Chicken Alfredo Bake

• Ingredients: Zoodles, chicken breast, Alfredo sauce (low-carb), mozzarella.
• Instructions: Mix cooked chicken and Alfredo with zoodles, spread in dish, sprinkle with mozzarella, bake 25 minutes at 350°F.

6. Sausage & Spinach Breakfast Casserole

• Ingredients: Sausage, eggs, spinach, cheddar cheese.
• Instructions: Cook sausage, whisk eggs with spinach, mix all, pour in dish, top with cheddar, bake 30 minutes at 350°F.

7. Greek Chicken Casserole

• Ingredients: Chicken breast, spinach, olives, feta cheese, oregano.
• Instructions: Place chicken in dish, top with spinach, olives, crumbled feta, and oregano. Bake 35 minutes at 375°F.

8. Tuna Zoodle Casserole

• Ingredients: Zucchini noodles, canned tuna, almond flour, mozzarella, mayo.
• Instructions: Mix tuna, mayo, and zoodles. Place in dish, top with almond flour and cheese, bake 20 minutes at 350°F.

9. Cauliflower Rice Enchilada Casserole

• Ingredients: Cauliflower rice, ground beef, enchilada sauce (sugar-free), cheddar.
• Instructions: Mix beef, sauce, and cauliflower rice. Spread in dish, top with cheddar, bake 25 minutes at 375°F.

10. Philly Cheesesteak Casserole

• Ingredients: Sliced beef, bell peppers, onions, provolone cheese.
• Instructions: Sauté beef, peppers, and onions. Spread in dish, cover with provolone, bake 20 minutes at 375°F.

11. Chicken Fajita Casserole

• Ingredients: Shredded chicken, bell peppers, onions, fajita seasoning, cheese.
• Instructions: Mix all ingredients, place in dish, sprinkle cheese, bake 25 minutes at 350°F.

12. Turkey & Cauliflower Shepherd’s Pie

• Ingredients: Ground turkey, cauliflower mash, butter, garlic powder, cheddar.
• Instructions: Cook turkey with spices. Spread in dish, top with cauliflower mash and cheese, bake 30 minutes at 375°F.

13. Egg & Veggie Bake

• Ingredients: Eggs, spinach, mushrooms, bell peppers, feta cheese.
• Instructions: Whisk eggs with veggies, pour into dish, top with feta, bake 25 minutes at 350°F.

14. Shrimp & Spinach Alfredo Casserole

• Ingredients: Shrimp, spinach, Alfredo sauce, mozzarella.
• Instructions: Mix shrimp, spinach, and Alfredo. Spread in dish, top with mozzarella, bake 20 minutes at 375°F.

15. BBQ Chicken Casserole

• Ingredients: Chicken breast, sugar-free BBQ sauce, cheddar cheese.
• Instructions: Mix chicken with BBQ sauce, place in dish, sprinkle cheddar, bake 20 minutes at 375°F.

16. Mushroom & Beef Stroganoff Casserole

• Ingredients: Ground beef, mushrooms, sour cream, beef broth, mozzarella.
• Instructions: Cook beef with mushrooms, stir in sour cream and broth, spread in dish, top with cheese, bake 25 minutes at 350°F.

17. Keto Pizza Casserole

• Ingredients: Ground beef, marinara (sugar-free), pepperoni, mozzarella.
• Instructions: Spread cooked beef with marinara as the base, add cheese and pepperoni, bake 25 minutes at 375°F.

18. Tex-Mex Chicken Casserole

• Ingredients: Chicken, cauliflower rice, jalapeños, salsa, cheddar.
• Instructions: Mix chicken, cauliflower rice, salsa, and jalapeños. Spread in dish, top with cheddar, bake 30 minutes at 375°F.

19. Zoodle Lasagna Casserole

• Ingredients: Zucchini noodles, ricotta, ground beef, marinara, mozzarella.
• Instructions: Layer zucchini, ricotta, beef with marinara, and cheese. Repeat layers, bake 40 minutes at 375°F.

20. Pesto Chicken & Veggie Bake

• Ingredients: Chicken thighs, zucchini, cherry tomatoes, pesto, mozzarella.
• Instructions: Mix all ingredients, spread in dish, bake 30 minutes at 375°F.

21. Cabbage & Ground Beef Casserole

• Ingredients: Cabbage, ground beef, tomato sauce, mozzarella.
• Instructions: Layer cooked cabbage with beef and tomato sauce. Top with cheese, bake 30 minutes at 375°F.

Tips for Perfect Casseroles

• Always pre-cook meat for best flavor.
• Use parchment paper to prevent sticking.
• Store leftovers in airtight containers for 4–5 days in fridge.

Final Thoughts

These 21 low-carb protein casseroles prove you can enjoy comfort food without the carbs. They’re quick, satisfying, and perfect for weight loss, meal prep, or family dinners.

Start with your favorite recipe, prep a batch, and fuel your week with delicious fat-burning meals.

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